|
KMID : 0545120020120050854
|
|
Journal of Microbiology and Biotechnology
2002 Volume.12 No. 5 p.854 ~ p.857
|
|
|
Antimicrobial Effects of Ocotillone Isolated from Stem Bark of Ailanthus altisshima
|
|
LEE, DONG GUN
CHANG, YOUNG-SU/PARK, YOONKYUNG/HAHM, KYUNG-SOO/WOO, EUN-RHAN
|
|
|
Abstract
|
|
|
|
Bioassay-directed chromatographic fractionation of a methylene chloride extract of Ailanthus altisshima indicated the presence of 20(S), 24(R), epoxy-25-hydroxydammarance-3-one (compound 1, ocotillone) which was isolated from this plant, for the first time. Antimicrobial activity of compound 1 was measured by inhibition of bacterial and fungal cells growth and by a hemolytic assay with human erythrocytes, respectively. The results revealed that compound 1 had potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that were without hemolytic activity, whereas it had weak antimicrobial activity against Gram-positive bacteria and fungi. These result demonstrated that the compound 1 has more antibacterial activity against Gram-negative bacteria, which have no hemolytic activity, than Gram-positive bacteria and fungi. This is the first report on the biological activities of the compound 1.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|